Edexcel GCSE Biology
Edexcel GCSE Biology revision for Edexcel Biology (1BI0): 9 topics and 165 short lessons, each with R.E.C.I.P.E. recall steps and a quiz. The topics follow the Edexcel specification.
1. Key concepts in biology
- Sub-cellular structures of eukaryotic and prokaryotic cells
- Specialised cells
- Microscope technology
- Number, size and scale
- Units and standard form for cells
- Core practical: using a light microscope
- Enzyme action, the active site and specificity
- Denaturing of enzymes
- Temperature, substrate concentration and pH
- Core practical: the effect of pH on enzyme activity
- Rate calculations for enzyme activity
- Enzymes in synthesis and breakdown
- Core practical: food tests for starch, reducing sugars, proteins and fats
- Measuring the energy in food using calorimetry
- Transport into and out of cells: diffusion, osmosis and active transport
- Core Practical: Investigate osmosis in potatoes
- Calculate percentage gain and loss of mass in osmosis
2. Cells and control
- Mitosis and the cell cycle
- Importance of mitosis
- Daughter cells and chromosomes
- Cancer and cell division
- Growth in animals and plants
- Importance of cell differentiation
- Percentile charts and growth
- Stem cells and meristems
- Benefits and risks of stem cells in medicine
- Describe the structures and functions of the brain including the cerebellum, cerebral hemispheres and medulla oblongata
- Explain how the difficulties of accessing brain tissue inside the skull can be overcome by using CT scanning and PET scanning to investigate brain function
- Explain some of the limitations in treating damage and disease in the brain and other parts of the nervous system, including spinal injuries and brain tumours
- Neurones, synapses and nerve impulses
- The reflex arc
- Structure and function of the eye
- Defects of the eye
- Correcting eye defects
3. Genetics
- Advantages and disadvantages of asexual reproduction
- Advantages and disadvantages of sexual reproduction
- Meiosis and the production of gametes
- The structure of DNA
- The genome and genes
- Extracting DNA from fruit, and how bases code for proteins
- From DNA bases to protein shape
- Protein synthesis: transcription and translation
- Variants in non-coding DNA
- Variants in coding DNA
- Mendel and the discovery of inheritance
- Alleles and inherited differences
- Key terms in genetics
- Monohybrid inheritance, Punnett squares and pedigrees
- Sex determination at fertilisation
- Calculating outcomes of monohybrid crosses
- Inheritance of the ABO blood groups
- Inheritance of sex-linked genetic disorders
- Multiple genes and phenotype
- Genetic variation and phenotype
- The Human Genome Project
- Genetic variation and mutations
- Effects of mutations on the phenotype
4. Natural selection and genetic modification
- Charles Darwin, Alfred Wallace and the theory of evolution
- Darwin's theory of evolution by natural selection
- Resistant organisms and natural selection
- Evidence for human evolution from fossils
- Evidence for human evolution from stone tools
- The pentadactyl limb as evidence for evolution
- Three domains and five kingdoms
- Selective breeding and tissue culture
- Tissue culture
- Genetic engineering
- Stages of genetic engineering and GM organisms
- Advantages and disadvantages of genetic engineering
- Agricultural solutions for a growing population
- Benefits and risks of genetic engineering and selective breeding
5. Health, disease and the development of medicines
- Health and the WHO definition
- Communicable and non-communicable diseases
- One disease leading to another
- Pathogens
- Common infections
- Spread and prevention of infections
- Lifecycle of a virus: lytic and lysogenic pathways
- Sexually transmitted infections: chlamydia and HIV
- Plant defences: physical barriers
- Plant defences: chemicals and medicines
- Detecting and identifying plant disease
- Physical barriers and chemical defences
- The specific immune response
- Immunisation, herd immunity and its pros and cons
- Advantages and disadvantages of immunisation
- Antibiotics and aseptic technique
- Aseptic techniques in culturing microorganisms
- Core practical: effects of antiseptics, antibiotics and plant extracts on microbial cultures
- Cross-sectional areas of bacterial cultures and clear agar jelly
- Developing new medicines
- Production of monoclonal antibodies
- Uses of monoclonal antibodies
- Causes of non-communicable diseases
- Lifestyle factors and non-communicable diseases
- Treatments for cardiovascular disease
6. Plant structures and their functions
- Photosynthetic organisms as producers of food and biomass
- Photosynthesis as an endothermic reaction
- Limiting factors on the rate of photosynthesis
- Interactions of limiting factors in photosynthesis
- Core practical: light intensity and the rate of photosynthesis
- Light intensity, distance and the inverse square law
- Root hair cells
- Xylem and phloem
- Transpiration and stomata
- Translocation of sucrose
- Leaf structure: adaptations for photosynthesis and gas exchange
- Factors affecting water uptake
- Transpiration rate calculations
- Plant adaptations to extreme environments
- Plant hormones, auxins, phototropism and gravitropism
- Commercial uses of auxins, gibberellins and ethene
7. Animal coordination, control and homeostasis
- Hormones and endocrine glands
- Adrenalin and fight or flight
- Thyroxine and negative feedback
- The menstrual cycle
- Hormone interactions in the menstrual cycle
- Hormonal contraception
- Evaluate hormonal and barrier methods of contraception
- Hormones in Assisted Reproductive Technology
- Homeostasis and the constant internal environment
- The importance of homeostasis
- Thermoregulation and the skin
- Shivering, vasoconstriction and vasodilation
- Insulin and blood glucose concentration
- Glucagon and blood glucose concentration
- Type 1 diabetes: cause and control
- Type 2 diabetes
- Body mass, BMI and type 2 diabetes
- Structure of the urinary system
- Structure of the nephron and filtration
- ADH and the collecting duct
- Treating kidney failure
- Urea production in the liver
8. Exchange and transport in animals
- Why substances must be transported
- Exchange surfaces and transport systems
- Alveoli and the rate of diffusion
- Factors affecting the rate of diffusion
- Calculating the rate of diffusion using Fick's law
- The structure and function of blood
- Arteries, veins and capillaries
- The heart and the circulatory system
- Cellular respiration
- Aerobic and anaerobic respiration compared
- Core practical: rate of respiration
- Heart rate, stroke volume and cardiac output
9. Ecosystems and material cycles
- Levels of organisation in an ecosystem
- Abiotic and biotic factors affecting communities
- Interdependence in a community
- Parasitism and mutualism
- Core practical: fieldwork with quadrats and belt transects
- Estimating population size from quadrat data
- Energy transfer and trophic levels
- Efficiency of energy transfer and percentage biomass
- Human interactions: fish farming and non-indigenous species
- Benefits of maintaining biodiversity
- Biological factors affecting food security
- How materials cycle in an ecosystem
- The carbon cycle
- The water cycle and potable water
- Nitrates and the nitrogen cycle
- Indicator species and pollution
- Decomposition and food preservation
- Decomposition and composting
- Calculate rate changes in the decay of biological material