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Preparation of Aliphatic Amines

Edexcel A-level ChemistryAmines, Amides, Amino Acids and ProteinsLesson 3 of 12

There are two main ways to make aliphatic amines.

1. Halogenoalkane and ammonia. A halogenoalkane is heated with excess ammonia dissolved in ethanol in a sealed tube (ammonia is a gas, so it would escape from an open flask). Ammonia acts as a nucleophile and substitutes for the halogen:

CH3CH2Br + 2NH3 → CH3CH2NH2 + NH4Br

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Key terms in this lesson

nitrile
An organic compound containing the carbon-nitrogen triple bond, C triple bond N (the cyano group).

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