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Amides

Edexcel A-level ChemistryAmines, Amides, Amino Acids and ProteinsLesson 7 of 12

Amides contain the functional group -CONH2: a carbonyl group bonded directly to a nitrogen atom. They are named from the parent carboxylic acid by replacing "-oic acid" with "-amide", so CH3CONH2 is ethanamide.

If one hydrogen on the nitrogen is replaced by an alkyl or aryl group, the compound is an N-substituted amide, such as N-methylethanamide, CH3CONHCH3.

Formation. Amides are made by reacting an acyl chloride with ammonia in a nucleophilic addition-elimination reaction. A second ammonia molecule reacts with the HCl formed:

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