BRAINCAKEFriedel-Crafts Acylation
Friedel-Crafts acylation substitutes an acyl group, RCO, onto a benzene ring, producing an aromatic ketone. It is an electrophilic substitution.
Reagents and conditions: an acyl chloride (e.g. ethanoyl chloride, CH3COCl) with an anhydrous aluminium chloride catalyst, heated under reflux in dry conditions.
Generating the electrophile: AlCl3 removes the chlorine to form an acylium ion, RCO+:
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More in Arenes
- Combustion of Benzene
- Electrophilic Substitution
- Bromination of Benzene
- Nitration of Benzene
- Friedel-Crafts Alkylation
- Phenol
- Reaction of Phenol with Bromine Water
- Why Phenol is More Reactive than Benzene
All 13 lessons in Arenes · All Edexcel A-level Chemistry topics