BRAINCAKEInduced Fit Hypothesis
The induced fit hypothesis was proposed by Daniel Koshland in 1958. It is a modified version of the lock and key hypothesis that better matches evidence about the structure of enzymes.
In this model:
• the active site is flexible, not rigid
• before the substrate binds, the active site is not exactly complementary to it
• as the substrate binds, it induces the active site to change shape, so the active site moulds itself around the substrate, giving a close fit
• this change in shape puts strain on bonds in the substrate, so they break more easily (or holds substrates in positions where new bonds form more easily)
Sign in free to see the rest of this lesson, the R.E.C.I.P.E. recall steps and the quiz
BrainCake is free. Make an account in seconds and pick up where this page stops.
Key terms in this lesson
- active site
- The region of an enzyme, with a shape complementary to its substrate, where the substrate molecule binds and the reaction is catalysed.
- activation energy
- The minimum amount of energy that colliding particles must have for a reaction to occur.
More in Enzymes
- Enzymes
- Extra-Cellular and Intracellular Enzymes
- Biological Catalysts
- Lock and Key Hypothesis
- Measuring Rate of Reaction
- Effect of Substrate Concentration
- Effect of Temperature
- Effect of pH
All 14 lessons in Enzymes · All Edexcel AS-level Biology topics