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End-Product Inhibition

Edexcel AS-level BiologyEnzymesLesson 14 of 14

End-product inhibition is a way that a cell controls a metabolic pathway: the final product of the pathway inhibits an enzyme that acts near the start of it. It is an example of negative feedback.

Most metabolic pathways are a chain of reactions, each catalysed by its own enzyme:

A → B → C → D (end product)
Diagram

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Key terms in this lesson

negative feedback
A control mechanism in which a change triggers a response that counteracts the change, returning a system towards a set level.
allosteric site
A site on an enzyme other than the active site to which a molecule can bind, changing the shape of the active site.

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