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The role of tRNA, mRNA and rRNA

There are three types of RNA: mRNA, tRNA and ribosomal RNA or rRNA.RNA has a sugar-phosphate backbone made of ribose and phosphate groups linked together by phosphodiester bonds.Thymine in DNA is replaced by uracil in RNA.mRNA is a long single strand of RNA arranged in a single helix. The base sequence of mRNA is a copy of the base sequence of the DNA sense strand for one gene.mRNA leaves the nucleus via nuclear pores where it attaches to a ribosome in the cytoplasm and determines the order in which amino acids are linked together to make polypeptides.Each triplet that specifies an amino acids is called a codon.tRNA is a relatively small molecules of around 80 nucleotides that is a single strand folded into a clover leaf shape by hydrogen bonding between bases.One end of the tRNA molecule extends beyond the other and this acts as an amino-acid binding site. Each tRNA molecule binds a different amino acid with an ester bond.At the other end three bases form the anticodon which is complementary to a codon on mRNA and temporarily binds to mRNA with hydrogen bonds. Uracil binds with adenine forming two hydrogen bonds and cytosine binds with guanine forming three hydrogen bonds. This is known as complementary base-pairing.The binding of the codon and anticodon is also by complementary base pairing.

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Specification: OCR Biology A (H020), AS-level, 2.1.3 Nucleotides and nucleic acids. Topic: Biological Molecules.

Key terms in this lesson

complementary base pairing
The specific pairing of bases in nucleic acids: adenine with thymine (or uracil), and cytosine with guanine, held together by hydrogen bonds.
codon
A sequence of three bases on mRNA that codes for a specific amino acid.
gene
A length of DNA that codes for a specific polypeptide.

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