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The Power Stroke

In the resting state the myosin head has ADP and Pi bound. Once the binding site is exposed the myosin head releases Pi and binds to the actin molecule forming a cross-bridge. ADP is released and the head bends pulling the actin towards the middle of the sarcomere. The binding of ATP breaks the cross-bridge and the myosin head detaches. Hydrolysis of ATP returns the myosin head to its resting state. It is then free to bind to another binding site further along.

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