BRAINCAKESickle-cell Anaemia
In sickle cell anaemia, abnormal haemoglobin clumps together deforming the shape of red blood cells and causing them to become sickle shaped. The red blood cells (erythrocytes) are less flexible and have difficulty squeezing through the capillaries. Not enough oxygen reaches the tissues due to reduced blood flow causing anaemia.
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Key terms in this lesson
- Codon
- A sequence of three bases on mRNA that codes for a specific amino acid or a stop signal.
- Mutation
- A change in the base sequence of DNA.
- Allele
- One of the different forms of a gene, arising from mutation, that occupies the same locus on homologous chromosomes.
More in Genetics and Variation
- The Genetic Code
- Mutations
- Effects of Mutations
- Change in Protein Function
- Causes of mutations
- Chromosome Mutations
- Gene Regulation
- Controlling Transcription
All 36 lessons in Genetics and Variation · All OCR A-level Biology topics