Change in Protein Function

• Amorph effect - the mutation results in a loss of function of the protein.
• Hypomorph effect - the mutation results in a reduction of function of the protein.
• Hypermorph - the mutation enhances the function of the protein.

Non-sense mutations lead to a stop codon replacing the codon for an amino-acid.

Mis-sense mutations lead to an amino-acid being replaced. Conservative mutations replace the amino-acid with one with similar properties. Non-conservative mutations replace the amino-acid with one with different properties.