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Neurotransmitters

Edexcel A-level BiologyMammalian Nervous SystemLesson 18 of 38

A neurotransmitter is a chemical released from a presynaptic neurone that diffuses across a synaptic cleft and binds to receptors on a postsynaptic cell, changing its membrane potential.

Examples include:

• Acetylcholine (ACh): used at neuromuscular junctions, in the parasympathetic nervous system and in parts of the brain. Synapses using ACh are cholinergic.
• Noradrenaline: used in the sympathetic nervous system and the brain. Synapses using it are adrenergic.
• Dopamine: used in the brain in movement, motivation and the reward pathway. A shortage in part of the brain causes Parkinson's disease.
• Serotonin: used in the brain in mood and sleep. Low levels are linked to depression.

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Key terms in this lesson

exocytosis
The process by which a cell releases a substance to the outside by fusing a vesicle with the cell surface membrane.

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