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Pre-synaptic Membrane

Edexcel A-level BiologyMammalian Nervous SystemLesson 16 of 38

The events at the presynaptic membrane turn an electrical signal (the action potential) into a chemical one (the release of neurotransmitter). At a cholinergic synapse:

1. An action potential arrives at the synaptic knob and depolarises the presynaptic membrane.

2. The depolarisation opens voltage-gated calcium ion channels in the presynaptic membrane.

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Key terms in this lesson

exocytosis
The process by which a cell releases a substance to the outside by fusing a vesicle with the cell surface membrane.

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