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Sex-Linked Diseases

Edexcel A-level BiologyGenetic InformationLesson 28 of 30

Sex-linked diseases are caused by faulty alleles of genes on the sex chromosomes. Most are X-linked recessive. Well-known examples include haemophilia, red-green colour blindness and Duchenne muscular dystrophy.

Because males have only one X chromosome, a male with one recessive allele (XaY) is affected. A female needs two recessive alleles (XaXa) to be affected; a female with one (XAXa) is an unaffected carrier.

Typical features of X-linked recessive inheritance:

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Key terms in this lesson

carrier
A heterozygous individual who carries a recessive allele for a condition without showing it themselves.

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