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Identifying Linked Genes

Edexcel A-level BiologyGenetic InformationLesson 23 of 30

Linkage is usually identified from the results of a dihybrid test cross, in which a double heterozygote (AaBb) is crossed with a double homozygous recessive (aabb).

If the genes are unlinked, the four phenotypes appear in a 1 : 1 : 1 : 1 ratio. If they are linked, the offspring show two large classes and two small classes:

• the two large classes have the parental combinations of characteristics (no crossing over between the genes)
• the two small classes are the recombinants, produced when crossing over separated the alleles

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