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Gene Linkage

Edexcel A-level BiologyGenetic InformationLesson 22 of 30

Each chromosome carries hundreds or thousands of genes. Genes found on the same chromosome are said to be linked (autosomal linkage when the chromosome is not a sex chromosome).

Linked genes do not assort independently. Because they are on the same chromosome, the alleles on that chromosome tend to be passed into the same gamete and inherited together. So Mendel's law of independent assortment does not apply to them.

Worked example: genes A and B are linked. A fly has A and B on one chromosome and a and b on its homologue (written AB/ab). Without crossing over it makes only two gamete types, AB and ab, instead of the four (AB, Ab, aB, ab) expected for unlinked genes.

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