BRAINCAKEGene Editing
Gene editing changes the base sequence of DNA at a precise, chosen place in the genome. The most widely used tool is CRISPR-Cas9, adapted from a system bacteria use to destroy viral DNA.
CRISPR-Cas9 has two parts:
• a guide RNA, designed with a base sequence complementary to the target DNA, which leads the enzyme to the right place
• Cas9, a nuclease that cuts both strands of the DNA at that site.
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Key terms in this lesson
- sickle cell disease
- An inherited blood disorder in which a mutant allele of the haemoglobin gene causes red blood cells to become rigid and sickle-shaped, impairing oxygen transport.
More in Gene Expression
- Epigenetic Control of Development
- Epigenetic Control of Gene Expression
- Stem Cell Therapy
- Therapeutic Cloning
- Potential Benefits of Stem Cell Therapy
- Pitfalls of Stem Cell Therapy
- Induced Pluripotent Stem Cells
- Diseases that Could Be Treated
All 39 lessons in Gene Expression · All Edexcel A-level Biology topics