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Pitfalls of Stem Cell Therapy

Edexcel A-level BiologyGene ExpressionLesson 29 of 39

Stem cell therapy also has serious risks and practical problems that must be solved before most treatments become routine.

Rejection
Stem cells from a donor, including most embryonic stem cells, have different antigens, so the patient's immune system may reject them. Immunosuppressant drugs reduce rejection but weaken the immune system, increasing the risk of infection.

Tumours
Stem cells divide readily. If they keep dividing out of control after transplantation they may form a tumour. Undifferentiated embryonic stem cells can form a teratoma, a tumour containing a mixture of tissues such as hair, muscle and bone. Every transplanted cell must therefore be fully differentiated.

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Key terms in this lesson

immunosuppressant drug
A drug that reduces the activity of the immune system, used to prevent rejection of transplanted cells or organs.
multipotent
Describes a cell able to differentiate into a limited range of related cell types.

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