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Advantages of iPS Cells

Edexcel A-level BiologyGene ExpressionLesson 39 of 39

Induced pluripotent stem cells (iPS cells) offer a way round many of the ethical problems of embryonic stem cells. Shinya Yamanaka shared the 2012 Nobel Prize in Physiology or Medicine for discovering how to make them.

Ethical advantages
• No embryo is created or destroyed.
• No donated eggs are needed, so there is no risk to egg donors.
• They are made from the patient's own cells, such as skin cells, so they are genetically identical to the patient, including their mitochondrial DNA, and should not be rejected.
• Cells can be collected with simple, consented procedures such as a skin biopsy.

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Key terms in this lesson

oncogene
A gene that, when mutated or overexpressed, can drive a cell towards becoming cancerous.
epigenetic
Relating to changes that affect how genes are expressed without changing the DNA base sequence itself.

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