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The Krebs Cycle.

AQA A-level BiologyRespirationLesson 7 of 12

The Krebs cycle also occurs in the matrix of the mitochondria. Acetyl coA reacts with 4-carbon oxaloacetate to form 6-carbon citrate and coA is released.

Citrate undergoes decarboxylation and dehydrogenation to form 5-carbon alpha ketogluarate (αKG). Carbon dioxide is released and NAD is reduced.

Diagram

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Key terms in this lesson

decarboxylation
The removal of carbon dioxide from a molecule, such as pyruvate during the link reaction or intermediates in the Krebs cycle.
dehydrogenation
The removal of hydrogen atoms from a molecule, typically coupled with the reduction of a coenzyme such as NAD or FAD.
ATP
Adenosine triphosphate, the universal energy currency of cells, formed by adding an inorganic phosphate to ADP and hydrolysed to release energy for cellular reactions.

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