The Krebs Cycle.
The Krebs cycle also occurs in the matrix of the mitochondria. Acetyl coA reacts with 4-carbon oxaloacetate to form 6-carbon citrate and coA is released.
Citrate undergoes decarboxylation and dehydrogenation to form 5-carbon alpha ketogluarate (αKG). Carbon dioxide is released and NAD is reduced.

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Key terms in this lesson
- decarboxylation
- The removal of carbon dioxide from a molecule, such as pyruvate during the link reaction or intermediates in the Krebs cycle.
- dehydrogenation
- The removal of hydrogen atoms from a molecule, typically coupled with the reduction of a coenzyme such as NAD or FAD.
- ATP
- Adenosine triphosphate, the universal energy currency of cells, formed by adding an inorganic phosphate to ADP and hydrolysed to release energy for cellular reactions.
More in Respiration
- Phosphorylation
- Lysis
- Substrate Level Phosphorylation
- The Link Reaction
- oxidative phosphorylation
- ATP Synthase
- ATP Synthase
- Anaerobic Respiration - Plants and Microorganisms.
All 12 lessons in Respiration · All AQA A-level Biology topics