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Two-Stage Synthetic Routes

OCR AS-level ChemistryOrganic SynthesisLesson 7 of 8

Sometimes a target compound cannot be made from the starting material in one step. A two-stage synthetic route converts the starting material into an intermediate, which is then converted into the product. For each stage, give the reagents and conditions and name the intermediate.

Useful AS reactions:
• alkene + steam, H3PO4 catalyst → alcohol
• alkene + HBr → bromoalkane
• haloalkane + NaOH(aq), heat under reflux → alcohol
• primary alcohol + H2SO4/K2Cr2O7: distil → aldehyde; excess oxidant, heat under reflux → carboxylic acid
• secondary alcohol + H2SO4/K2Cr2O7, heat under reflux → ketone
• alcohol + acid catalyst (H2SO4 or H3PO4), heat → alkene

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Key terms in this lesson

functional group
A group of atoms in a molecule responsible for its characteristic chemical reactions.

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