BRAINCAKEGrignard Reagents and Carbon Dioxide
Grignard reagents react with carbon dioxide to make carboxylic acids. This is a way of adding one carbon atom to a chain and forming a -COOH group at the same time.
The reaction happens in two stages. First, the nucleophilic δ− carbon of the Grignard reagent attacks the δ+ carbon of CO2. Carbon dioxide is usually added as crushed solid carbon dioxide (dry ice), or bubbled through the solution as a dry gas. An intermediate magnesium salt forms:
CH3CH2MgBr + CO2 → CH3CH2COOMgBr
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More in Organic Synthesis
- Grignard Reagents
- Preparing Grignard Reagents
- Grignard Reagents and Carbonyl Compounds
- Organic Synthesis
- Synthetic Routes
- Practical Techniques - Heating under Reflux
- Recrystallisation
- Melting and Boiling Point Determination
All 11 lessons in Organic Synthesis · All Edexcel A-level Chemistry topics