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Carbonic Anhydrase

OCR AS-level BiologyTransport in AnimalsLesson 31 of 32

Carbonic anhydrase is an enzyme found in high concentration in the cytoplasm of red blood cells. It catalyses the reversible reaction between carbon dioxide and water to form carbonic acid:

CO2 + H2O ⇌ H2CO3

This reaction happens only slowly in the plasma, which contains little carbonic anhydrase. In red blood cells the enzyme speeds it up enormously, so carbon dioxide from respiring tissues is converted rapidly. The carbonic acid then dissociates into hydrogen ions and hydrogencarbonate ions:

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Key terms in this lesson

chloride shift
The movement of chloride ions into red blood cells to balance the charge lost when hydrogencarbonate ions diffuse out.

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