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Respiration of Proteins

OCR A-level BiologyRespirationLesson 16 of 19

Proteins are respired only when carbohydrate and lipid stores are low, for example during prolonged starvation. They are first hydrolysed by protease enzymes into amino acids.

Amino acids cannot be respired directly, because they contain nitrogen in their amine group (NH2). In mammals, excess amino acids are deaminated in the liver: the amine group is removed and forms ammonia. Ammonia is very toxic, so it is converted into urea in the ornithine cycle and excreted by the kidneys.

The part of the amino acid that remains is a keto acid (an organic acid). Depending on the amino acid, the keto acid is converted into:

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Key terms in this lesson

keto acid
The organic acid that remains after the amine group is removed from an amino acid during deamination.

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