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Repolarisation

After depolarisation the inside of the axon membrane is at about +40 mV. At this point the voltage-gated sodium ion channels close, so no more Na+ ions can diffuse into the axon.At the same time the voltage-gated potassium ion channels open. The membrane becomes much more permeable to K+ ions, which diffuse out of the axon down their electrochemical gradient. The inside of the axon is positively charged and has a high concentration of K+, so both the concentration gradient and the repulsion between positive charges move K+ outwards.As positive ions leave, the potential difference across the membrane falls back towards a negative value. This return of the membrane potential towards the resting potential is called repolarisation.Repolarisation is the falling phase on a trace of an action potential. The sodium ions cannot follow the potassium ions out, because the sodium channels are closed. The potassium channels are slow to close, which leads to the overshoot described in the next stage.

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Specification: OCR Biology A (H420), A-level, 5.1.3 Neuronal communication. Topic: Neuronal Communication.

Key terms in this lesson

Actin
A thin protein filament in a myofibril that, together with myosin, slides during muscle contraction.
Myosin
A thick protein filament in a myofibril with globular heads that bind to actin and pull it during muscle contraction.
Tropomyosin
A protein that winds around actin filaments and blocks the myosin-binding sites in a relaxed muscle.
Troponin
A globular protein complex bound to tropomyosin that binds calcium ions, causing tropomyosin to move and expose the myosin-binding sites on actin.
ATP
Adenosine triphosphate, the universal energy currency of cells, which releases energy for cellular reactions when hydrolysed to ADP and inorganic phosphate.

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