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The Fight or Flight Response

OCR A-level BiologyHormonal CommunicationLesson 12 of 19

When a mammal detects a threat, such as a predator, its body prepares either to fight or to run away. This is the fight or flight response. It is coordinated by the hypothalamus and involves both the nervous system and hormones.

1. Receptors detect the threat and impulses pass to the cerebrum, which recognises the danger and stimulates the hypothalamus.
2. The hypothalamus activates the sympathetic nervous system. Sympathetic neurones stimulate effectors directly, and also stimulate the adrenal medulla to release adrenaline into the blood.
3. The hypothalamus also releases corticotropin releasing factor (CRF) into the blood. This causes the anterior pituitary gland to release adrenocorticotropic hormone (ACTH), which stimulates the adrenal cortex to release corticosteroids such as cortisol.

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Key terms in this lesson

adrenal medulla
The inner part of the adrenal gland that secretes adrenaline and noradrenaline into the blood when stimulated by sympathetic neurones.
pituitary gland
An endocrine gland at the base of the brain, controlled by the hypothalamus, that secretes hormones controlling other endocrine glands and processes.

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