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Autosomal Linkage and Recombinant Offspring

OCR A-level BiologyGenetics and VariationLesson 41 of 41

Genes on the same autosome (a chromosome that is not a sex chromosome) are linked. Autosomal linkage means the alleles on one chromosome tend to be inherited together, because they do not assort independently in meiosis.

In a dihybrid cross of two unlinked genes, AaBb × aabb gives a 1 : 1 : 1 : 1 ratio. If the genes are linked, with A and B on one chromosome and a and b on the other, most gametes are AB or ab (the parental combinations). The offspring are mostly like the parents, and the 1 : 1 : 1 : 1 ratio is not seen.

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