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Net Gain of ATP

Edexcel A-level BiologyCellular RespirationLesson 20 of 20

Adding up the products of each stage shows how much ATP aerobic respiration can make from one glucose molecule.

Products per glucose:
• Glycolysis: net 2 ATP, 2 reduced NAD
• Link reaction (×2): 2 reduced NAD
• Krebs cycle (×2): 2 ATP, 6 reduced NAD, 2 reduced FAD
• Total: 4 ATP made by substrate-level phosphorylation, 10 reduced NAD and 2 reduced FAD

Most ATP is made by oxidative phosphorylation. Reduced FAD enters the electron transport chain further along than reduced NAD, so it yields less ATP.

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Key terms in this lesson

nad
A coenzyme (nicotinamide adenine dinucleotide) that acts as a hydrogen acceptor in respiration, becoming reduced when it accepts hydrogen from a substrate.
fad
A coenzyme (flavin adenine dinucleotide) that acts as a hydrogen acceptor at one step of the Krebs cycle, becoming reduced when it accepts hydrogen.

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