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Glycolysis

Edexcel A-level BiologyCellular RespirationLesson 9 of 20

Glycolysis (sugar splitting) is the first stage of both aerobic and anaerobic respiration. It takes place in the cytoplasm and converts one molecule of glucose (6C) into two molecules of pyruvate (3C).

Diagram

The main steps are:
1. Phosphorylation: two ATP molecules are hydrolysed and their phosphate groups are added to glucose, forming hexose bisphosphate. This makes the sugar more reactive.
2. Splitting: hexose bisphosphate splits into two 3-carbon molecules of triose phosphate.
3. Oxidation: hydrogen is removed from each triose phosphate by a dehydrogenase and accepted by NAD, forming reduced NAD.

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Key terms in this lesson

nad
A coenzyme (nicotinamide adenine dinucleotide) that acts as a hydrogen acceptor in respiration, becoming reduced when it accepts hydrogen from a substrate.

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