Producing Monoclonal Antibodies

1. Mice are exposed to the non-self antigen for which the antibodies are required.

2. The mouse B cells producing the required antibodies are extracted from the mouse spleen.

Sign in free to see the rest of this lesson, the R.E.C.I.P.E. recall steps and the quiz

BrainCake is free. Make an account in seconds and pick up where this page stops.

antigen: A protein or glycoprotein, usually on a cell surface, that is recognised as foreign by the immune system and triggers an immune response.
antibody: A Y-shaped protein, made of four polypeptide chains with variable regions complementary to a specific antigen, produced by B plasma cells.
B-lymphocyte: A type of white blood cell, matured in the bone marrow, responsible for the humoral immune response and antibody production.
monoclonal antibody: An antibody produced from a single clone of B cells, identical in structure and specific to one antigen.