Rough ER
The rough endoplasmic reticulum (RER) is a system of flattened, membrane-bound sacs called cisternae, whose outer surface is covered with ribosomes. This gives it its 'rough' appearance in electron micrographs. The RER membranes are continuous with the outer membrane of the nuclear envelope, and the fluid-filled space inside the sacs is the lumen.
Function
The RER makes and transports proteins, especially those that will be:
• secreted from the cell (such as digestive enzymes, hormones and antibodies)
• inserted into the cell surface membrane or other membranes
• sent to lysosomes
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Key terms in this lesson
- vesicle
- A small, membrane-bound sac used to transport or store materials within a cell, or to move them to or from the cell surface membrane.
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