Deletion of Bases

Base deletions almost always lead to loss of function of the protein as they involve a shift of the reading frame to the leftThey are therefore called frameshift mutations.Base deletions occur during DNA replication when a nucleotide fails to be incorporated into the new strand.They result in a different sequence of amino acids being added to the polypeptide chain from the point of the deletion.Cystic fibrosis is caused by a three-nucleotide deletion causing one amino-acid to be lost.