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Eradicating Disease

Edexcel A-level BiologyResponse to InfectionLesson 19 of 20

Eradication means a disease has been removed from the whole world, so there are no more cases anywhere and control measures such as vaccination can stop. This is different from elimination, where a disease is removed from one country or region but still exists elsewhere.

Smallpox is the only human disease to have been eradicated. The World Health Organization ran a global vaccination campaign, the last natural case was in 1977 and smallpox was declared eradicated in 1980. Rinderpest, a disease of cattle, was declared eradicated in 2011.

Smallpox was a good target for several reasons:
• the virus showed very little antigenic variability, so one vaccine worked everywhere and for life

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Key terms in this lesson

antigenic variability
The extent to which a pathogen's antigens change over time or between strains, which can allow it to evade immune memory.

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