Reactions of Amines as Nucleophiles
When ammonia in an ethanol solvent reacts with a halogenoalkane a primary amine is produced by the nucleophilic substitution of the halide by an NH2 group. However, the primary amine produced is also a nucleophile and in turn reacts with the halogenoalkane to form a secondary amine.

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Key terms in this lesson
- nucleophile
- An atom or group of atoms that can donate a pair of electrons to form a new covalent bond.
- nucleophilic substitution
- A reaction mechanism in which a nucleophile donates a lone pair of electrons to an electron-deficient carbon atom, displacing a leaving group.
More in Nitrogen Compounds
- Amines
- Properties of Amines
- Basicity of Amines
- Synthesis of Amines
- Reactions of Amines as Bases
- Economic Importance of Amines
All 7 lessons in Nitrogen Compounds · All OCR A-level Organic Chemistry topics