BRAINCAKEFriedel-Crafts Acylation
In Friedel-Crafts acylation, benzene reacts with an acyl chloride in the presence of a halogen carrier such as AlCl3, under anhydrous conditions. The product is an aromatic ketone, and a new carbon-carbon bond forms to the ring.
Mechanism (electrophilic substitution)
1. The halogen carrier generates the electrophile, an acylium ion:
CH3COCl + AlCl3 → CH3CO+ + AlCl4−
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Key terms in this lesson
- acyl chloride
- A carboxylic acid derivative in which the -OH of the carboxyl group is replaced by -Cl.
More in Benzene
- Halogenation of Benzene
- Phenol
- Halogen Carriers
- Friedel-Crafts Alkylation
- Reactivity of Phenol
- Phenol as a Weak Acid
- Bromination of Phenol
- Nitration of Phenol
All 16 lessons in Benzene · All OCR A-level Organic Chemistry topics