When ammonia in an ethanol solvent reacts with a halogenoalkane a primary amine is produced by the nucleophilic substitution of the halide by an NH2 group. However, the primary amine produced is also a nucleophile and in turn reacts with the halogenoalkane to form a secondary amine.The secondary amine reacts to form a tertiary amine and the tertiary amine reacts to form a quaternary ammonium salt.The nucleophilic substitution reaction of ammonia and a halogenoalkane is not a very efficient way of preparing an amine because of the further substitutions. The ammonia in a large excess will give a better yield of the primary amine.
Reactions of Amines as Nucleophiles
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Specification: OCR Chemistry A (H432), A-level. Topic: Nitrogen Compounds.
More in Nitrogen Compounds
- Amines
- Properties of Amines
- Basicity of Amines
- Synthesis of Amines
- Reactions of Amines as Bases
- Economic Importance of Amines
All 7 lessons in Nitrogen Compounds · All OCR A-level Chemistry topics